This thesis explores the pivotal role of mitochondria in the process of skin aging and the pathogenesis of various skin diseases. Skin aging, a multifactorial and inevitable biological process, is significantly influenced by mitochondrial function. Recent advances in dermatological and cellular research have demonstrated that mitochondrial dysfunction is associated with oxidative stress, DNA damage, and reduced bioenergetic capacity, all of which contribute to both intrinsic and extrinsic aging processes. Through an extensive literature review and critical analysis of recent studies, this thesis provides comprehensive insights into how mitochondrial dynamics, including biogenesis, mitophagy, and reactive oxygen species (ROS) production, contribute to skin health and disease. This work aims to synthesize current knowledge and identify potential therapeutic targets for delaying skin aging and treating mitochondrial-related skin disorders.
